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    2019

  • Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

    Leemans, M., Couderq, S., Demeneix, B., & Fini, J.-B.

    Frontiers in Endocrinology, 10, 1 (2019) https://doi.org/10.3389/fendo.2019.00743

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  • Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

    López-Tobón, A., Villa, C. E., Cheroni, C., Trattaro, S., Caporale, N., Conforti, P., Iennaco, R., Lachgar, M., Rigoli, M. T., Marcó de la Cruz, B., Lo Riso, P., Tenderini, E., Troglio, F., De Simone, M., Liste-Noya, I., Macino, G., Pagani, M., Cattaneo, E., & Testa, G.

    Stem Cell Reports, 13(5), 847–861. https://doi.org/10.1016/j.stemcr.2019.09.005

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  • SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

    Karreman, C., Kranaster, P. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 36(3), pp. 518-520. doi: 10.14573/altex.1906251.

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  • Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

    Dreser, N., Madjar, K., Holzer, A.-K., Kapitza, M., Scholz, C., Kranaster, P., Gutbier, S., Klima, S., Kolb, D., Dietz, C., Trefzer, T., Meisig, J., van Thriel, C., Henry, M., Berthold, M. R., Blüthgen, N., Sachinidis, A., Rahnenführer, J., Hengstler, J. G., … Leist, M.

    Archives of Toxicology, 2019, 94(1), 151–171. https://doi.org/10.1007/s00204-019-02612-5

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  • Association of urinary bisphenols and triclosan with thyroid function during early pregnancy

    Derakhshan, A., Shu, H., Peeters, R. P., Kortenkamp, A., Lindh, C. H., Demeneix, B., Bornehag, C.-G., & Korevaar, T. I. M.

    Environment International, 2019, 133, 105123. https://doi.org/10.1016/j.envint.2019.105123

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  • Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data

    Codaccioni, M., Bois, F., & Brochot, C.

    Computational Toxicology, 2019, 12, 100111, https://doi.org/10.1016/j.comtox.2019.100111

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  • In silico predictions of endocrine disruptors properties.

    Schneider M, Pons JL, Labesse G, Bourguet W.

    Endocrinology. 2019 Jul 2. pii: en.2019-00382. [Epub ahead of print] PubMed PMID: 31265055.

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  • Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity.

    Schneider M, Pons JL, Bourguet W, Labesse G.

    Bioinformatics. 2019 Jul 26. pii: btz538. [Epub ahead of print] PubMed PMID: 31350558

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    • 2020

  • The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

    Lupu, D., Andersson, P., Bornehag, C.-G., Demeneix, B., Fritsche, E., Gennings, C., Lichtensteiger, W., Leist, M., Leonards, P. E. G., Ponsonby, A.-L., Scholze, M., Testa, G., Tresguerres, J. A. F., Westerink, R. H. S., Zalc, B., & Rüegg, J.

    International Journal of Molecular Sciences, 21(11), 3978 (2020) https://doi.org/10.3390/ijms21113978

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  • Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

    Cheroni, C., Caporale, N., & Testa, G.

    Molecular Autism 11, 69 (2020). https://doi.org/10.1186/s13229-020-00370-1

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  • Erratum to Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data

    Krebs, A., Waldmann, T., Wilks, M. F., van Vugt-Lussenburg, B. M. A., van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T., Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2020, 37(1), p. 164. Available at: https://www.altex.org/index.php/altex/article/view/1508

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  • Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

    Krebs, A., Nyffeler, J., Karreman, C., Schmidt, B. Z., Kappenberg, F., Mellert, J., Pallocca, G., Pastor, M., Rahnenführer, J. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2020, 37(1), pp. 155-163. doi: 10.14573/altex.1912021.

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  • CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

    Karreman, C., Klima, S., Holzer, A.-K. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 37(2), pp. 332-336. doi: 10.14573/altex.2003191

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  • Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

    Brüll, M., Spreng, A.-S., Gutbier, S., Loser, D., Krebs, A., Reich, M., Kraushaar, U., Britschgi, M., Patsch, C. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2020, 37(3), pp. 409-428. doi: 10.14573/altex.1911111.

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  • Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven

    Tanner, E. M., Hallerbäck, M. U., Wikström, S., Lindh, C., Kiviranta, H., Gennings, C., & Bornehag, C.-G.

    Environment International, 2020, 134, 105185. https://doi.org/10.1016/j.envint.2019.105185

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  • Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

    Couderq, S., Leemans, M., & Fini, J.-B.

    Molecular and Cellular Endocrinology, 508, 110779. https://doi.org/10.1016/j.mce.2020.110779

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  • QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances

    Chinen, K. K., Klimenko, K., Taxvig, C., Nikolov, N. G., & Wedebye, E. B.

    Computational Toxicology, 14, 100121. https://doi.org/10.1016/j.comtox.2020.100121

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  • Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells : proof of multiple mechanism-based toxicity

    Allard, J., Bucher, S., Massart, J., Ferron, P.-J., Le Guillou, D., Loyant, R., Daniel, Y., Launay, Y., Buron, N., Begriche, K., Borgne-Sanchez, A., & Fromenty, B.

    Cell Biology and Toxicology, 2020, https://doi.org/10.1007/s10565-020-09537-1

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  • The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds

    Legler, J., Zalko, D., Jourdan, F., Jacobs, M., Fromenty, B., Balaguer, P., Bourguet, W., Munic Kos, V., Nadal, A., Beausoleil, C., Cristobal, S., Remy, S., Ermler, S., Margiotta-Casaluci, L., Griffin, J. L., Blumberg, B., Chesné, C., Hoffmann, S., Andersson, P. L., & Kamstra, J. H.

    International Journal of Molecular Sciences, 21(10), 3480. https://doi.org/10.3390/ijms21103480

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  • Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

    den Broeder, M.J., Ballangby, J., Kamminga, L.M. et al.

    Epigenetics & Chromatin 13, 5 (2020). https://doi.org/10.1186/s13072-020-0329-y

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  • SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

    Moroni, L., Barbaro, F., Caiment, F., Coleman, O., Costagliola, S., Di Conza, G., Elviri, L., Giselbrecht, S., Krause, C., Mota, C., Nazzari, M., Pennington, S. R., Ringwald, A., Sandri, M., Thomas, S., Waddington, J., & Toni, R.

    International Journal of Molecular Sciences, 2020, 21(10), 3648. https://doi.org/10.3390/ijms21103648

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  • Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

    Wagner, M., Yoshihara, M., Douagi, I., Damdimopoulos, A., Panula, S., Petropoulos, S., Lu, H., Pettersson, K., Palm, K., Katayama, S., Hovatta, O., Kere, J., Lanner, F., & Damdimopoulou, P.

    Nature Communications volume 11, Article number: 1147 (2020), https://doi.org/10.1038/s41467-020-14936-3

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  • Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

    Johansson, H. K. L., Svingen, T., Boberg, J., Fowler, P. A., Stead, D., Vinggaard, A. M., & Filis, P.

    Archives of Toxicology volume 94, pages 1241–1250 (2020), https://doi.org/10.1007/s00204-020-02697-3

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  • Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women

    Björvang, R. D., & Damdimopoulou, P.

    Upsala Journal of Medical Sciences, 125(2), 85–94, https://doi.org/10.1080/03009734.2020.1727073

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  • Dynamics of the transcriptional landscape during human fetal testis and ovary development

    Lecluze, E., Rolland, A. D., Filis, P., Evrard, B., Leverrier-Penna, S., Maamar, M. B., Coiffec, I., Lavoué, V., Fowler, P. A., Mazaud-Guittot, S., Jégou, B., & Chalmel, F.

    Human Reproduction, Volume 35, Issue 5, May 2020, Pages 1099–1119, https://doi.org/10.1093/humrep/deaa041

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  • Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

    van Duursen, M. B. M., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A.-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Bay Wedebye, E., … van den Berg, M.

    International Journal of Molecular Sciences, 2020, 21(9), 3215, https://doi.org/10.3390/ijms21093215

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  • Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

    Talia, C., Raja, E.-A., Bhattacharya, S., & Fowler, P. A.

    Human Reproduction, 2020, 35(7), 1702–1711, https://doi.org/10.1093/humrep/deaa091

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  • Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

    Johansson, H. K. L., Damdimopoulou, P., van Duursen, M. B. M., Boberg, J., Franssen, D., de Cock, M., Jääger, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumets, A., Draskau, M. K., Filis, P., Fowler, P. A., Christiansen, S., Parent, A.-S., & Svingen, T.

    Archives of Toxicology, 2020, 94(10), 3359–3379, https://doi.org/10.1007/s00204-020-02834-y

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  • Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals

    Taboureau, O., El M’Selmi, W., & Audouze, K.

    Toxicology and Applied Pharmacology, 2020, 405, 115210, https://doi.org/10.1016/j.taap.2020.115210

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  • Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption

    Knapen, D., Stinckens, E., Cavallin, J., Ankley, G., Holbech, H., Villeneuve, D. and Vergauwen, L.

    Environmental Science & Technology, 2020, 54(14), pp. 8491−8499, https://doi.org/10.1021/acs.est.9b07205

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  • Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish

    Stinckens, E., Vergauwen, L., Blackwell, B., Ankley, G., Villeneuve, D. and Knapen, D.

    Environmental Science & Technology, 2020, 54(10), pp.6213-6223, https://doi.org/10.1021/acs.est.9b07204

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  • A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons.

    Richard S, Guyot R, Rey-Millet M, Prieux M, Markossian S, Aubert D and Flamant F.

    iScience, 2020, 23 (3): 100899, https://doi.org/10.1016/J.ISCI.2020.100899

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  • Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project.

    Audouze, K.; Sarigiannis, D.; Alonso-Magdalena, P.; Brochot, C.; Casas, M.; Vrijheid, M.; Babin, P.J.; Karakitsios, S.; Coumoul, X.; Barouki, R.

    International Journal of Molecular Sciences 2020, 21, 2988, https://doi.org/10.3390/ijms21082988

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  • ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters.

    Holbech, H.; Matthiessen, P.; Hansen, M.; Schüürmann, G.; Knapen, D.; Reuver, M.; Flamant, F.; Sachs, L.; Kloas, W.; Hilscherova, K.; Leonard, M.; Arning, J.; Strauss, V.; Iguchi, T.; Baumann, L.

    International Journal of Molecular Sciences 2020, 21, 2954, https://doi.org/10.3390/ijms21082954

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  • The EDCMET Project: Metabolic Effects of Endocrine Disruptors.

    Küblbeck, J.; Vuorio, T.; Niskanen, J.; Fortino, V.; Braeuning, A.; Abass, K.; Rautio, A.; Hakkola, J.; Honkakoski, P.; Levonen, A.-L.

    International Journal of Molecular Sciences 2020, 21, 3021, https://doi.org/10.3390/ijms21083021

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  • Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals – The ATHENA Project

    Kortenkamp A, Axelstad M, Baig AH, Bergman A, Bornehag C-G, Cenijn P, Christiansen S, Demeneix B, Derakhshan A, Fini J-B, Frädrich C, Hamers T, Hellwig L, Kӧhrle J, Korevaar TIM, Lindberg J, Martin O, Meima ME, Mergenthaler P, Nikolov N, Du Pasquier D, Peeters RP, Platzack B, Ramhøj L, Remaud S, Renko K, Scholze M, Stachelscheid H, Svingen T, Wagenaars F, Wedebye EB and Zoeller RT.

    The ATHENA Project. Int. J. Mol. Sci. 2020, 21(9), 3123, https://doi.org/10.3390/ijms21093123

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