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    2019

  • SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging.

    Karreman, C., Kranaster, P. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2019; 36(3), pp. 518-520

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  • Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

    Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M.

    ALTEX - Alternatives to animal experimentation, 2019;36(4):682-699

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  • Mother-child transfer rates of organohalogen compounds up to four years of age

    Mercè Garí, Joan O. Grimalt, Esther Vizcaino, Adonina Tardón, Ana Fernández-Somoano

    Environment International, Issue 133, 2019, Page(s) 105241, ISSN 0160-4120

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  • Drivers of maternal accumulation of organohalogen pollutants in Arctic areas (Chukotka, Russia) and 4,4′-DDT effects on the newborns

    Natalia Bravo, Joan O. Grimalt, Max Chashchin, Valery P. Chashchin, Jon-Øyvind Odland

    Environment International, Issue 124, 2019, Page(s) 541-552, ISSN 0160-4120

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  • Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

    Leemans, M., Couderq, S., Demeneix, B., & Fini, J.-B.

    Frontiers in Endocrinology, 10, 1 (2019) https://doi.org/10.3389/fendo.2019.00743

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  • Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

    López-Tobón, A., Villa, C. E., Cheroni, C., Trattaro, S., Caporale, N., Conforti, P., Iennaco, R., Lachgar, M., Rigoli, M. T., Marcó de la Cruz, B., Lo Riso, P., Tenderini, E., Troglio, F., De Simone, M., Liste-Noya, I., Macino, G., Pagani, M., Cattaneo, E., & Testa, G.

    Stem Cell Reports, 13(5), 847–861. https://doi.org/10.1016/j.stemcr.2019.09.005

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  • SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

    Karreman, C., Kranaster, P. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 36(3), pp. 518-520. doi: 10.14573/altex.1906251.

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  • Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

    Dreser, N., Madjar, K., Holzer, A.-K., Kapitza, M., Scholz, C., Kranaster, P., Gutbier, S., Klima, S., Kolb, D., Dietz, C., Trefzer, T., Meisig, J., van Thriel, C., Henry, M., Berthold, M. R., Blüthgen, N., Sachinidis, A., Rahnenführer, J., Hengstler, J. G., … Leist, M.

    Archives of Toxicology, 2019, 94(1), 151–171. https://doi.org/10.1007/s00204-019-02612-5

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  • Association of urinary bisphenols and triclosan with thyroid function during early pregnancy

    Derakhshan, A., Shu, H., Peeters, R. P., Kortenkamp, A., Lindh, C. H., Demeneix, B., Bornehag, C.-G., & Korevaar, T. I. M.

    Environment International, 2019, 133, 105123. https://doi.org/10.1016/j.envint.2019.105123

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  • Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data

    Codaccioni, M., Bois, F., & Brochot, C.

    Computational Toxicology, 2019, 12, 100111, https://doi.org/10.1016/j.comtox.2019.100111

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  • In silico predictions of endocrine disruptors properties.

    Schneider M, Pons JL, Labesse G, Bourguet W.

    Endocrinology. 2019 Jul 2. pii: en.2019-00382. [Epub ahead of print] PubMed PMID: 31265055.

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  • Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity.

    Schneider M, Pons JL, Bourguet W, Labesse G.

    Bioinformatics. 2019 Jul 26. pii: btz538. [Epub ahead of print] PubMed PMID: 31350558

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  • 2020

  • Organophosphate metabolite concentrations in maternal urine during pregnancy

    Natalia Bravo, Soraya Peralta, Joan O. Grimalt, Maria Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher

    Environmental Research, Issue 182, 2020, Page(s) 109003, ISSN 0013-9351

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  • Urinary cobalt and ferritin in four-years-old children

    Eva Junqué, Joan O. Grimalt, Ana Fernández-Somoano, Adonina Tardón

    Environmental Research, Issue 183, 2020, Page(s) 109147, ISSN 0013-9351

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  • Changes of organochlorine compound concentrations in maternal serum during pregnancy and comparison to serum cord blood composition

    Eva Junqué, Sergi Garcia, María Ángeles Martínez, Joaquim Rovira, Marta Schuhmacher, Joan O. Grimalt

    Environmental Research, Issue 182, 2020, Page(s) 108994, ISSN 0013-9351

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  • Mother/child organophosphate and pyrethroid distributions

    Natalia Bravo, Joan O. Grimalt, Darja Mazej, Janja Snoj Tratnik, Dimosthenis Andreas Sarigiannis, Milena Horvat

    Environment International, Issue 134, 2020, Page(s) 105264, ISSN 0160-4120

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  • Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

    Jenni Küblbeck, Jonna Niskanen, Paavo Honkakoski

    Cells, Volume 9, 2020, 2306, ISSN 2073-4409

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  • PXR and 4β-Hydroxycholesterol Axis and the Components of Metabolic Syndrome

    Janne Hukkanen, Jukka Hakkola

    Cells, Volume 9, 2020, 2445, ISSN 2073-4409

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  • Regulation of Thyroid-disrupting Chemicals to Protect the Developing Brain

    Mary E Gilbert, Katherine L O’Shaughnessy, Marta Axelstad

    Endocrinology, Volume 161, Issue 10, October 2020, bqaa106

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  • Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective

    Barbara Demeneix, Laura N Vandenberg, Richard Ivell, R Thomas Zoeller

    Journal of the Endocrine Society, Volume 4, Issue 10, October 2020, bvaa085

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  • Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: Cohort study of 151,141 singleton pregnancies

    Aikaterini Zafeiri, Edwin A. Raja, Rod T. Mitchell, David C. Hay, Sohinee Bhattacharya, Paul A. Fowler

    medRxiv

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  • The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

    Lupu, D., Andersson, P., Bornehag, C.-G., Demeneix, B., Fritsche, E., Gennings, C., Lichtensteiger, W., Leist, M., Leonards, P. E. G., Ponsonby, A.-L., Scholze, M., Testa, G., Tresguerres, J. A. F., Westerink, R. H. S., Zalc, B., & Rüegg, J.

    International Journal of Molecular Sciences, 21(11), 3978 (2020) https://doi.org/10.3390/ijms21113978

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  • Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

    Cheroni, C., Caporale, N., & Testa, G.

    Molecular Autism 11, 69 (2020). https://doi.org/10.1186/s13229-020-00370-1

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  • Erratum to Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data

    Krebs, A., Waldmann, T., Wilks, M. F., van Vugt-Lussenburg, B. M. A., van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T., Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2020, 37(1), p. 164. Available at: https://www.altex.org/index.php/altex/article/view/1508

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  • Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

    Krebs, A., Nyffeler, J., Karreman, C., Schmidt, B. Z., Kappenberg, F., Mellert, J., Pallocca, G., Pastor, M., Rahnenführer, J. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2020, 37(1), pp. 155-163. doi: 10.14573/altex.1912021.

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  • CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

    Karreman, C., Klima, S., Holzer, A.-K. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 37(2), pp. 332-336. doi: 10.14573/altex.2003191

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  • Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

    Brüll, M., Spreng, A.-S., Gutbier, S., Loser, D., Krebs, A., Reich, M., Kraushaar, U., Britschgi, M., Patsch, C. and Leist, M.

    ALTEX - Alternatives to animal experimentation, 2020, 37(3), pp. 409-428. doi: 10.14573/altex.1911111.

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  • Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven

    Tanner, E. M., Hallerbäck, M. U., Wikström, S., Lindh, C., Kiviranta, H., Gennings, C., & Bornehag, C.-G.

    Environment International, 2020, 134, 105185. https://doi.org/10.1016/j.envint.2019.105185

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  • Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

    Couderq, S., Leemans, M., & Fini, J.-B.

    Molecular and Cellular Endocrinology, 508, 110779. https://doi.org/10.1016/j.mce.2020.110779

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  • QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances

    Chinen, K. K., Klimenko, K., Taxvig, C., Nikolov, N. G., & Wedebye, E. B.

    Computational Toxicology, 14, 100121. https://doi.org/10.1016/j.comtox.2020.100121

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  • Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells : proof of multiple mechanism-based toxicity

    Allard, J., Bucher, S., Massart, J., Ferron, P.-J., Le Guillou, D., Loyant, R., Daniel, Y., Launay, Y., Buron, N., Begriche, K., Borgne-Sanchez, A., & Fromenty, B.

    Cell Biology and Toxicology, 2020, https://doi.org/10.1007/s10565-020-09537-1

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  • The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds

    Legler, J., Zalko, D., Jourdan, F., Jacobs, M., Fromenty, B., Balaguer, P., Bourguet, W., Munic Kos, V., Nadal, A., Beausoleil, C., Cristobal, S., Remy, S., Ermler, S., Margiotta-Casaluci, L., Griffin, J. L., Blumberg, B., Chesné, C., Hoffmann, S., Andersson, P. L., & Kamstra, J. H.

    International Journal of Molecular Sciences, 21(10), 3480. https://doi.org/10.3390/ijms21103480

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  • Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish

    den Broeder, M.J., Ballangby, J., Kamminga, L.M. et al.

    Epigenetics & Chromatin 13, 5 (2020). https://doi.org/10.1186/s13072-020-0329-y

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  • SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

    Moroni, L., Barbaro, F., Caiment, F., Coleman, O., Costagliola, S., Di Conza, G., Elviri, L., Giselbrecht, S., Krause, C., Mota, C., Nazzari, M., Pennington, S. R., Ringwald, A., Sandri, M., Thomas, S., Waddington, J., & Toni, R.

    International Journal of Molecular Sciences, 2020, 21(10), 3648. https://doi.org/10.3390/ijms21103648

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  • Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

    Wagner, M., Yoshihara, M., Douagi, I., Damdimopoulos, A., Panula, S., Petropoulos, S., Lu, H., Pettersson, K., Palm, K., Katayama, S., Hovatta, O., Kere, J., Lanner, F., & Damdimopoulou, P.

    Nature Communications volume 11, Article number: 1147 (2020), https://doi.org/10.1038/s41467-020-14936-3

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  • Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

    Johansson, H. K. L., Svingen, T., Boberg, J., Fowler, P. A., Stead, D., Vinggaard, A. M., & Filis, P.

    Archives of Toxicology volume 94, pages 1241–1250 (2020), https://doi.org/10.1007/s00204-020-02697-3

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  • Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women

    Björvang, R. D., & Damdimopoulou, P.

    Upsala Journal of Medical Sciences, 125(2), 85–94, https://doi.org/10.1080/03009734.2020.1727073

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  • Dynamics of the transcriptional landscape during human fetal testis and ovary development

    Lecluze, E., Rolland, A. D., Filis, P., Evrard, B., Leverrier-Penna, S., Maamar, M. B., Coiffec, I., Lavoué, V., Fowler, P. A., Mazaud-Guittot, S., Jégou, B., & Chalmel, F.

    Human Reproduction, Volume 35, Issue 5, May 2020, Pages 1099–1119, https://doi.org/10.1093/humrep/deaa041

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  • Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

    van Duursen, M. B. M., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A.-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Bay Wedebye, E., … van den Berg, M.

    International Journal of Molecular Sciences, 2020, 21(9), 3215, https://doi.org/10.3390/ijms21093215

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  • Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

    Talia, C., Raja, E.-A., Bhattacharya, S., & Fowler, P. A.

    Human Reproduction, 2020, 35(7), 1702–1711, https://doi.org/10.1093/humrep/deaa091

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  • Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

    Johansson, H. K. L., Damdimopoulou, P., van Duursen, M. B. M., Boberg, J., Franssen, D., de Cock, M., Jääger, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumets, A., Draskau, M. K., Filis, P., Fowler, P. A., Christiansen, S., Parent, A.-S., & Svingen, T.

    Archives of Toxicology, 2020, 94(10), 3359–3379, https://doi.org/10.1007/s00204-020-02834-y

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  • Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals

    Taboureau, O., El M’Selmi, W., & Audouze, K.

    Toxicology and Applied Pharmacology, 2020, 405, 115210, https://doi.org/10.1016/j.taap.2020.115210

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  • Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption

    Knapen, D., Stinckens, E., Cavallin, J., Ankley, G., Holbech, H., Villeneuve, D. and Vergauwen, L.

    Environmental Science & Technology, 2020, 54(14), pp. 8491−8499, https://doi.org/10.1021/acs.est.9b07205

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  • Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish

    Stinckens, E., Vergauwen, L., Blackwell, B., Ankley, G., Villeneuve, D. and Knapen, D.

    Environmental Science & Technology, 2020, 54(10), pp.6213-6223, https://doi.org/10.1021/acs.est.9b07204

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  • A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons.

    Richard S, Guyot R, Rey-Millet M, Prieux M, Markossian S, Aubert D and Flamant F.

    iScience, 2020, 23 (3): 100899, https://doi.org/10.1016/J.ISCI.2020.100899

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  • Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project.

    Audouze, K.; Sarigiannis, D.; Alonso-Magdalena, P.; Brochot, C.; Casas, M.; Vrijheid, M.; Babin, P.J.; Karakitsios, S.; Coumoul, X.; Barouki, R.

    International Journal of Molecular Sciences 2020, 21, 2988, https://doi.org/10.3390/ijms21082988

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  • ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters.

    Holbech, H.; Matthiessen, P.; Hansen, M.; Schüürmann, G.; Knapen, D.; Reuver, M.; Flamant, F.; Sachs, L.; Kloas, W.; Hilscherova, K.; Leonard, M.; Arning, J.; Strauss, V.; Iguchi, T.; Baumann, L.

    International Journal of Molecular Sciences 2020, 21, 2954, https://doi.org/10.3390/ijms21082954

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  • The EDCMET Project: Metabolic Effects of Endocrine Disruptors.

    Küblbeck, J.; Vuorio, T.; Niskanen, J.; Fortino, V.; Braeuning, A.; Abass, K.; Rautio, A.; Hakkola, J.; Honkakoski, P.; Levonen, A.-L.

    International Journal of Molecular Sciences 2020, 21, 3021, https://doi.org/10.3390/ijms21083021

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  • Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals – The ATHENA Project

    Kortenkamp A, Axelstad M, Baig AH, Bergman A, Bornehag C-G, Cenijn P, Christiansen S, Demeneix B, Derakhshan A, Fini J-B, Frädrich C, Hamers T, Hellwig L, Kӧhrle J, Korevaar TIM, Lindberg J, Martin O, Meima ME, Mergenthaler P, Nikolov N, Du Pasquier D, Peeters RP, Platzack B, Ramhøj L, Remaud S, Renko K, Scholze M, Stachelscheid H, Svingen T, Wagenaars F, Wedebye EB and Zoeller RT.

    The ATHENA Project. Int. J. Mol. Sci. 2020, 21(9), 3123, https://doi.org/10.3390/ijms21093123

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  • 2021

  • Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic.

    Zekri, Y., Flamant, F., & Gauthier, K.

    Cells, 10(6), 1327.

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  • Sex chromosomes in so-called “asexual” hybrid vertebrates: along the ‘extended speciation continuum’.

    Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K.

    European Society of Evolutionary Biology (ESEB) Satellite Symposium Genomic signatures and consequences of sex and asexuality 16.06.2021 – 17.06.2021, all times indicated are CEST Hosts Astrid Böhne, ZFMK and Philipp Schiffer, University of Cologne.

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  • Sex Chromosomes in Meiotic, Hemiclonal, Clonal and Polyploid Hybrid Vertebrates: Along the ‘Extended Speciation Continuum.

    Stöck, M., Dedukh, D., Reifová, R., Lamatsch, D.K., Starostová, Z. and Janko, K.

    Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, p. 20200103.

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  • Expanding the Classical Paradigm: What We Have Learnt from Vertebrates about Sex Chromosome Evolution.

    Kratochvíl, L., Stöck, M., Rovatsos, M., Bullejos, M., Herpin, A., Jeffries, D.L., Peichel, C.L., Perrin, N., Valenzuela, N. and Johnson Pokorná, N.

    Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376, no. 1833, p. 20200097.

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  • Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes

    Saranya Palaniswamy S, Khaled Abass, Jaana Rysä, Jon Øyvind Odland, Joan O. Grimalt, Arja Rautio, Marjo-Riitta Järvelin

    Environment International, Volume 156, 2021, 106766, ISSN 0160-4120

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  • Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2-mediated mechanism

    Mikko Karpale, Aki Juhani Käräjämäki, Outi Kummu, Helena Gylling, Tuulia Hyötyläinen, Matej Oresic, Ari Tolonen, Heidi Hautajärvi, Markku J Savolainen, Mika Ala-Korpela, Janne Hukkanen, Jukka Hakkola

    British Journal of Pharmacology, Volume 178, 2021, 2461, ISSN1476-5381

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  • A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity

    Amirhossein Sakhteman, Mario Failli, Jenni Küblbeck, Anna-Liisa Levonen, Vittorio Fortino

    Environmental International, Volume 156, 2021, 106751, ISSN 0160-4120

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  • Association of urinary bisphenols during pregnancy with maternal, cord blood and childhood thyroid function

    Arash Derakhshan Elise M. Philips Akhgar Ghassabian Susana Santos Alexandros G.A Simakopouloshi Kurunthachalam Kannanefj Andreas Kortenkam Vincent W.V. Jaddoecd Leonardo Trasande Robin P. Peeters Tim I.M. Korevaar

    Environment International Volume 146, January 2021, 106160

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  • Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures

    Vanessa Delfosse, Tiphaine Huet, Deborah Harrus, Meritxell Granell, Maxime Bourguet, Caroline Gardia-Parège, Barbara Chiavarina, Marina Grimaldi, Sébastien Le Mével, Pauline Blanc, David Huang, Jakub Gruszczyk, Barbara Demeneix, Sarah Cianférani, Jean-Baptiste Fini, Patrick Balaguer, and William Bourguet

    PNAS January 5, 2021 118 (1) e2020551118

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  • Association of phthalate exposure with thyroid function during pregnancy

    Arash Derakhshan Huan Shu Maarten A.C. Broeren Christian H. Lindh Robin P. Peeters Andreas Kortenkamp Barbara Demeneix Carl-Gustaf Bornehagch Tim I.M. Korevaara

    Environment International Volume 157, December 2021, 106795

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  • Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities

    Christopher J. Martyniuk , Ruben Martínez , Laia Navarro-Martín , Jorke H. Kamstra , Adam Schwendt , Stephane Reynaud , Lorraine Chalifour

    Environmental Research

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  • Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study

    Christopher D. Kassotisa Kate Hoffman Johannes Völker Yong Pud Almudena Veiga-Lopez Stephanie M. Kime Jennifer J. Schlezingere Patrizia Bovolin Erika Cottone Astrid Saraceni Rosaria Scandiffiof Ella Atlasg Karen Leingartnerg Stacey Krager Shelley A. Tischkauh Sibylle Ermleri Juliette Legler Vesna A.Chappell Suzanne E. Fenton Fahmi Mesmar Maria Bondesso Mariana F. Fernández Heather M. Stapleton

    Toxicology Volume 461, September 2021, 152900

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  • Six Decades of Research on Human Fetal Gonadal Steroids

    Stéphane Connan-Perrot, Thibaut Léger, Pauline Lelandais, Christèle Desdoits-Lethimonier, Arthur David, Paul A. Fowler and Séverine Mazaud-Guittot

    Int. J. Mol. Sci. 2021, 22(13), 6681

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  • A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation

    Terje Svingen, Daniel L Villeneuve, Dries Knapen, Eleftheria Maria Panagiotou, Monica Kam Draskau, Pauliina Damdimopoulou, Jason M O’Brien

    Toxicological Sciences, Volume 184, Issue 2, December 2021, Pages 183–190

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  • The insulin-like growth factor system: A target for endocrine disruptors?

    Chiara Talia Lisa Connolly Paul A. Fowler

    Environment International Volume 147, February 2021, 106311

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  • Evidenced-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities

    Audouze, K., Zgheib, E., Abass, K., Baig, A., Forner-Piquer, I., Holbech, H., Knapen, D., Leonards, P., Lupu, D., Palaniswamy, S., Rautio, A., Sapounidou, M. and Martin, O.

    Frontiers in Toxicology

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  • Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

    Rousseau, K., Dufour, S. and Sachs, L. M.

    Frontiers in Ecology and Evolution, 9.

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  • In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors.

    Zekri, Y., Agnol, L.D, Flamant, F. and Guyot, R.

    iScience, 102957.

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  • Mechanistic evaluation of rodent studies for selected thyroid disrupting chemicals (TDCs). From key events to adverse outcome pathway.

    Steinbach, A.M.

    (Unpublished Master’s thesis). University of Milan and BASF SE.

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  • Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study

    Kubickova, B., Ramwell, C., Hilscherova, K. and Jacobs, M.N.

    Environmental Sciences Europe 33, 20

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  • Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase

    Ramhøj, L., Frädrich, C., Svingen, T., Scholze, M., Wirth, E. K., Rijntjes, E., Köhrle, J., Kortenkamp, A., & Axelstad, M.

    Environmental Pollution, 283, 117135. https://doi.org/10.1016/j.envpol.2021.117135

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  • The mammalian ovary: concerns about evaluation of prenatal environmental exposures

    Lecante, L. L., Lelandais, P., Séverine Mazaud-Guittot, S., & Fowler, P.

    Current Opinion in Endocrine and Metabolic Research, 1. https://doi.org/10.1016/j.coemr.2021.03.012

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  • Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

    Güil-Oumrait, N., Valvi, D., Garcia-Esteban, R., Guxens, M., Sunyer, J., Torrent, M., Casas, M., & Vrijheid, M.

    Environment International Volume 151, June 2021, 106469. DOI: https://doi.org/10.1016/j.envint.2021.106469

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  • A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals

    Franssen D. · Svingen T. · Lopez Rodriguez D. · Van Duursen M. · Boberg J. · Parent A.

    Neuroendocrinology 2021. https://doi.org/10.1159/000515478

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  • Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole

    Derakhshan, A., Shu, H., Peeters, R. P., Kortenkamp, A., Lindh, C. H., Demeneix, B., Bornehag, C.-G., & Korevaar, T. I. M.

    Environment International, 133, 105123. https://doi.org/10.1016/j.envint.2019.105123

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  • Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

    Street, M. E., Audouze, K., Legler, J., Sone, H., & Palanza, P.

    International Journal of Molecular Sciences, 22(2), 933. https://doi.org/10.3390/ijms22020933

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  • 2022

  • Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice.

    Zekri Y, Guyot R, Suñer IG, Canaple L, Stein AG, Petit JV, Aubert D, Richard S, Flamant F, Gauthier K.

    Elife 11: e81996.

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  • An Atlas of Thyroid Hormone Receptors’ Target Genes in Mouse Tissues.

    Zekri Y, Guyot R, and Flamant F.

    International Journal of Molecular Sciences 23(19): 11444.

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  • Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system.

    Tribondeau, A., Sachs, L.M. and Buisine, N.

    Frontiers in Genetics 13:996826.

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  • Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen

    Flamant, F., Zekri, Y. and Guyot, R.

    Endocrinology, bqac084.

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  • A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice

    Affortit, C., Blanc, F., Nasr, J., Ceccato, J.C., Markossian, S., Guyot, R., Puel, J.L., Flamant, F. and Wang, J.

    Science signaling, 15 (738), eabj4583.

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  • Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis

    Bidisha, P., Sterner, Z.R., Buchholz, D.R., Shi, Y.B. and Sachs, L.M.

    Cells 11, no. 10: 1595

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  • Plastic Nanoparticles Cause Mild Inflammation, Disrupt Metabolic Pathways, Change the Gut Microbiota and Affect Reproduction in Zebrafish: A Full Generation Multi-Omics Study.

    Maranaa, M.H., Poulsen, R., Thormar, E.A., Clausen, C.G., Thitd, A., Mathiessen, H., Jaafar, R., Korbut, R., Magdalene, A., Hansen, B., Hansen, M., Limborg, M.T., Syberg, K., von Gersdorff Jørgensen, L.

    Journal of Hazardous Materials, vol. 424, p. 127705.

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  • PFOS-Induced Thyroid Hormone System Disrupted Rats Display Organ-Specific Changes in Their Transcriptomes.

    Davidsen, N., Ramhøj, L., Lykkebo, C.A., Kugathas, I., Poulsen, R., Rosenmai, A.K., Evrard, B., Darde., T.A., Axelstad, M., Bahl, M.I., Hansen, M., Chalmel, F., Licht, T.R. and Svingen, T.

    Environmental Pollution, p.119340

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  • Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain.

    Hamdaoui, Q., Zekri, Y., Richard, S., Aubert, D., Guyot, R., Markossian, S., Gauthier, K., Gaie-Levrel, F., Bencsik, A., & Flamant, F.

    Chemosphere, 287, 132253.

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  • Thyroid‐like hormone signalling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals.

    Morthorst, J., Holbech, H., de Crozé, N., Matthiessen, P., and LeBlanc, G.

    Integrated Environmental Assessment and Management.

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  • Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring

    Louise Ramhøja Terje Svingena Caroline Frädrich Eddy Rijntjes Eva K. Wirth Katrine Pedersen Josef Köhrle Marta Axelstad

    Toxicology Letters Volume 354, 1 January 2022, Pages 44-55

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