Filters
-
Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data
Leemans, M., Couderq, S., Demeneix, B., & Fini, J.-B.
Frontiers in Endocrinology, 10, 1 (2019) https://doi.org/10.3389/fendo.2019.00743
View publication -
Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis
López-Tobón, A., Villa, C. E., Cheroni, C., Trattaro, S., Caporale, N., Conforti, P., Iennaco, R., Lachgar, M., Rigoli, M. T., Marcó de la Cruz, B., Lo Riso, P., Tenderini, E., Troglio, F., De Simone, M., Liste-Noya, I., Macino, G., Pagani, M., Cattaneo, E., & Testa, G.
Stem Cell Reports, 13(5), 847–861. https://doi.org/10.1016/j.stemcr.2019.09.005
View publication -
SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging
Karreman, C., Kranaster, P. and Leist, M.
ALTEX - Alternatives to animal experimentation, 36(3), pp. 518-520. doi: 10.14573/altex.1906251.
View publication -
Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances
Dreser, N., Madjar, K., Holzer, A.-K., Kapitza, M., Scholz, C., Kranaster, P., Gutbier, S., Klima, S., Kolb, D., Dietz, C., Trefzer, T., Meisig, J., van Thriel, C., Henry, M., Berthold, M. R., Blüthgen, N., Sachinidis, A., Rahnenführer, J., Hengstler, J. G., … Leist, M.
Archives of Toxicology, 2019, 94(1), 151–171. https://doi.org/10.1007/s00204-019-02612-5
View publication -
Association of urinary bisphenols and triclosan with thyroid function during early pregnancy
Derakhshan, A., Shu, H., Peeters, R. P., Kortenkamp, A., Lindh, C. H., Demeneix, B., Bornehag, C.-G., & Korevaar, T. I. M.
Environment International, 2019, 133, 105123. https://doi.org/10.1016/j.envint.2019.105123
View publication -
Placental transfer of xenobiotics in pregnancy physiologically-based pharmacokinetic models: Structure and data
Codaccioni, M., Bois, F., & Brochot, C.
Computational Toxicology, 2019, 12, 100111, https://doi.org/10.1016/j.comtox.2019.100111
View publication -
In silico predictions of endocrine disruptors properties.
Schneider M, Pons JL, Labesse G, Bourguet W.
Endocrinology. 2019 Jul 2. pii: en.2019-00382. [Epub ahead of print] PubMed PMID: 31265055.
View publication -
Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity.
Schneider M, Pons JL, Bourguet W, Labesse G.
Bioinformatics. 2019 Jul 26. pii: btz538. [Epub ahead of print] PubMed PMID: 31350558
View publication -
The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
Lupu, D., Andersson, P., Bornehag, C.-G., Demeneix, B., Fritsche, E., Gennings, C., Lichtensteiger, W., Leist, M., Leonards, P. E. G., Ponsonby, A.-L., Scholze, M., Testa, G., Tresguerres, J. A. F., Westerink, R. H. S., Zalc, B., & Rüegg, J.
International Journal of Molecular Sciences, 21(11), 3978 (2020) https://doi.org/10.3390/ijms21113978
View publication -
Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology
Cheroni, C., Caporale, N., & Testa, G.
Molecular Autism 11, 69 (2020). https://doi.org/10.1186/s13229-020-00370-1
View publication -
Erratum to Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data
Krebs, A., Waldmann, T., Wilks, M. F., van Vugt-Lussenburg, B. M. A., van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T., Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. and Leist, M.
ALTEX - Alternatives to animal experimentation, 2020, 37(1), p. 164. Available at: https://www.altex.org/index.php/altex/article/view/1508
View publication -
Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays
Krebs, A., Nyffeler, J., Karreman, C., Schmidt, B. Z., Kappenberg, F., Mellert, J., Pallocca, G., Pastor, M., Rahnenführer, J. and Leist, M.
ALTEX - Alternatives to animal experimentation, 2020, 37(1), pp. 155-163. doi: 10.14573/altex.1912021.
View publication -
CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes
Karreman, C., Klima, S., Holzer, A.-K. and Leist, M.
ALTEX - Alternatives to animal experimentation, 37(2), pp. 332-336. doi: 10.14573/altex.2003191
View publication -
Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies
Brüll, M., Spreng, A.-S., Gutbier, S., Loser, D., Krebs, A., Reich, M., Kraushaar, U., Britschgi, M., Patsch, C. and Leist, M.
ALTEX - Alternatives to animal experimentation, 2020, 37(3), pp. 409-428. doi: 10.14573/altex.1911111.
View publication -
Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven
Tanner, E. M., Hallerbäck, M. U., Wikström, S., Lindh, C., Kiviranta, H., Gennings, C., & Bornehag, C.-G.
Environment International, 2020, 134, 105185. https://doi.org/10.1016/j.envint.2019.105185
View publication -
Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models
Couderq, S., Leemans, M., & Fini, J.-B.
Molecular and Cellular Endocrinology, 508, 110779. https://doi.org/10.1016/j.mce.2020.110779
View publication -
QSAR modeling of different minimum potency levels for in vitro human CAR activation and inhibition and screening of 80,086 REACH and 54,971 U.S. substances
Chinen, K. K., Klimenko, K., Taxvig, C., Nikolov, N. G., & Wedebye, E. B.
Computational Toxicology, 14, 100121. https://doi.org/10.1016/j.comtox.2020.100121
View publication -
Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells : proof of multiple mechanism-based toxicity
Allard, J., Bucher, S., Massart, J., Ferron, P.-J., Le Guillou, D., Loyant, R., Daniel, Y., Launay, Y., Buron, N., Begriche, K., Borgne-Sanchez, A., & Fromenty, B.
Cell Biology and Toxicology, 2020, https://doi.org/10.1007/s10565-020-09537-1
View publication -
The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds
Legler, J., Zalko, D., Jourdan, F., Jacobs, M., Fromenty, B., Balaguer, P., Bourguet, W., Munic Kos, V., Nadal, A., Beausoleil, C., Cristobal, S., Remy, S., Ermler, S., Margiotta-Casaluci, L., Griffin, J. L., Blumberg, B., Chesné, C., Hoffmann, S., Andersson, P. L., & Kamstra, J. H.
International Journal of Molecular Sciences, 21(10), 3480. https://doi.org/10.3390/ijms21103480
View publication -
Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish
den Broeder, M.J., Ballangby, J., Kamminga, L.M. et al.
Epigenetics & Chromatin 13, 5 (2020). https://doi.org/10.1186/s13072-020-0329-y
View publication -
SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner
Moroni, L., Barbaro, F., Caiment, F., Coleman, O., Costagliola, S., Di Conza, G., Elviri, L., Giselbrecht, S., Krause, C., Mota, C., Nazzari, M., Pennington, S. R., Ringwald, A., Sandri, M., Thomas, S., Waddington, J., & Toni, R.
International Journal of Molecular Sciences, 2020, 21(10), 3648. https://doi.org/10.3390/ijms21103648
View publication -
Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
Wagner, M., Yoshihara, M., Douagi, I., Damdimopoulos, A., Panula, S., Petropoulos, S., Lu, H., Pettersson, K., Palm, K., Katayama, S., Hovatta, O., Kere, J., Lanner, F., & Damdimopoulou, P.
Nature Communications volume 11, Article number: 1147 (2020), https://doi.org/10.1038/s41467-020-14936-3
View publication -
Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat
Johansson, H. K. L., Svingen, T., Boberg, J., Fowler, P. A., Stead, D., Vinggaard, A. M., & Filis, P.
Archives of Toxicology volume 94, pages 1241–1250 (2020), https://doi.org/10.1007/s00204-020-02697-3
View publication -
Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women
Björvang, R. D., & Damdimopoulou, P.
Upsala Journal of Medical Sciences, 125(2), 85–94, https://doi.org/10.1080/03009734.2020.1727073
View publication -
Dynamics of the transcriptional landscape during human fetal testis and ovary development
Lecluze, E., Rolland, A. D., Filis, P., Evrard, B., Leverrier-Penna, S., Maamar, M. B., Coiffec, I., Lavoué, V., Fowler, P. A., Mazaud-Guittot, S., Jégou, B., & Chalmel, F.
Human Reproduction, Volume 35, Issue 5, May 2020, Pages 1099–1119, https://doi.org/10.1093/humrep/deaa041
View publication -
Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project
van Duursen, M. B. M., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P. A., Gadella, B. M., Holte, J., Jääger, K., Johansson, H. K. L., Li, T., Mazaud-Guittot, S., Parent, A.-S., Salumets, A., Soto, A. M., Svingen, T., Velthut-Meikas, A., Bay Wedebye, E., … van den Berg, M.
International Journal of Molecular Sciences, 2020, 21(9), 3215, https://doi.org/10.3390/ijms21093215
View publication -
Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland
Talia, C., Raja, E.-A., Bhattacharya, S., & Fowler, P. A.
Human Reproduction, 2020, 35(7), 1702–1711, https://doi.org/10.1093/humrep/deaa091
View publication -
Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals
Johansson, H. K. L., Damdimopoulou, P., van Duursen, M. B. M., Boberg, J., Franssen, D., de Cock, M., Jääger, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumets, A., Draskau, M. K., Filis, P., Fowler, P. A., Christiansen, S., Parent, A.-S., & Svingen, T.
Archives of Toxicology, 2020, 94(10), 3359–3379, https://doi.org/10.1007/s00204-020-02834-y
View publication -
Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals
Taboureau, O., El M’Selmi, W., & Audouze, K.
Toxicology and Applied Pharmacology, 2020, 405, 115210, https://doi.org/10.1016/j.taap.2020.115210
View publication -
Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption
Knapen, D., Stinckens, E., Cavallin, J., Ankley, G., Holbech, H., Villeneuve, D. and Vergauwen, L.
Environmental Science & Technology, 2020, 54(14), pp. 8491−8499, https://doi.org/10.1021/acs.est.9b07205
View publication -
Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish
Stinckens, E., Vergauwen, L., Blackwell, B., Ankley, G., Villeneuve, D. and Knapen, D.
Environmental Science & Technology, 2020, 54(10), pp.6213-6223, https://doi.org/10.1021/acs.est.9b07204
View publication -
A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons.
Richard S, Guyot R, Rey-Millet M, Prieux M, Markossian S, Aubert D and Flamant F.
iScience, 2020, 23 (3): 100899, https://doi.org/10.1016/J.ISCI.2020.100899
View publication -
Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project.
Audouze, K.; Sarigiannis, D.; Alonso-Magdalena, P.; Brochot, C.; Casas, M.; Vrijheid, M.; Babin, P.J.; Karakitsios, S.; Coumoul, X.; Barouki, R.
International Journal of Molecular Sciences 2020, 21, 2988, https://doi.org/10.3390/ijms21082988
View publication -
ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters.
Holbech, H.; Matthiessen, P.; Hansen, M.; Schüürmann, G.; Knapen, D.; Reuver, M.; Flamant, F.; Sachs, L.; Kloas, W.; Hilscherova, K.; Leonard, M.; Arning, J.; Strauss, V.; Iguchi, T.; Baumann, L.
International Journal of Molecular Sciences 2020, 21, 2954, https://doi.org/10.3390/ijms21082954
View publication -
The EDCMET Project: Metabolic Effects of Endocrine Disruptors.
Küblbeck, J.; Vuorio, T.; Niskanen, J.; Fortino, V.; Braeuning, A.; Abass, K.; Rautio, A.; Hakkola, J.; Honkakoski, P.; Levonen, A.-L.
International Journal of Molecular Sciences 2020, 21, 3021, https://doi.org/10.3390/ijms21083021
View publication -
Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals – The ATHENA Project
Kortenkamp A, Axelstad M, Baig AH, Bergman A, Bornehag C-G, Cenijn P, Christiansen S, Demeneix B, Derakhshan A, Fini J-B, Frädrich C, Hamers T, Hellwig L, Kӧhrle J, Korevaar TIM, Lindberg J, Martin O, Meima ME, Mergenthaler P, Nikolov N, Du Pasquier D, Peeters RP, Platzack B, Ramhøj L, Remaud S, Renko K, Scholze M, Stachelscheid H, Svingen T, Wagenaars F, Wedebye EB and Zoeller RT.
The ATHENA Project. Int. J. Mol. Sci. 2020, 21(9), 3123, https://doi.org/10.3390/ijms21093123
View publication -
The mammalian ovary: concerns about evaluation of prenatal environmental exposures
Lecante, L. L., Lelandais, P., Séverine Mazaud-Guittot, S., & Fowler, P.
Current Opinion in Endocrine and Metabolic Research, 1. https://doi.org/10.1016/j.coemr.2021.03.012
View publication -
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents
Güil-Oumrait, N., Valvi, D., Garcia-Esteban, R., Guxens, M., Sunyer, J., Torrent, M., Casas, M., & Vrijheid, M.
Environment International Volume 151, June 2021, 106469. DOI: https://doi.org/10.1016/j.envint.2021.106469
View publication -
A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals
Franssen D. · Svingen T. · Lopez Rodriguez D. · Van Duursen M. · Boberg J. · Parent A.
Neuroendocrinology 2021. https://doi.org/10.1159/000515478
View publication -
Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole
Derakhshan, A., Shu, H., Peeters, R. P., Kortenkamp, A., Lindh, C. H., Demeneix, B., Bornehag, C.-G., & Korevaar, T. I. M.
Environment International, 133, 105123. https://doi.org/10.1016/j.envint.2019.105123
View publication -
Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs
Street, M. E., Audouze, K., Legler, J., Sone, H., & Palanza, P.
International Journal of Molecular Sciences, 22(2), 933. https://doi.org/10.3390/ijms22020933
View publication