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Review on toxic effects of DEHP (phthalate) on zebrafish embryos

Commonly used as a plasticiser in consumer products, DEHP (di(2-ethylhexyl) phthalate) has been associated with adverse health effects, such as reproductive abnormalities and metabolic diseases. In the past 10 years, an increasing number of DEHP toxicity studies have been using zebrafish embryos as an in vivo model due to their high fecundity, rapid embryonic development as well as optical transparency, which have now been established as an alternative of the more conventional rodent model. The aim of the present paper is to review the effects of acute (from embryo stage to 1 week) and chronic (from embryo stage to >1 week) DEHP exposures on zebrafish. 

DOI: https://doi.org/10.3390/toxics9080193

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